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Methylation associated inactivation of RASSF1A and its synergistic effect with activated K-Ras in nasopharyngeal carcinoma

Overview of attention for article published in Journal of Experimental & Clinical Cancer Research, December 2009
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1 peer review site

Citations

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28 Dimensions

Readers on

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35 Mendeley
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Title
Methylation associated inactivation of RASSF1A and its synergistic effect with activated K-Ras in nasopharyngeal carcinoma
Published in
Journal of Experimental & Clinical Cancer Research, December 2009
DOI 10.1186/1756-9966-28-160
Pubmed ID
Authors

Tao Wang, Hongli Liu, Yeshan Chen, Wei Liu, Jing Yu, Gang Wu

Abstract

Epigenetic silencing of tumor suppressor genes associated with promoter methylation is considered to be a hallmark of oncogenesis. RASSF1A is a candidate tumor suppressor gene which was found to be inactivated in many human cancers. Although we have had a preliminary cognition about the function of RASSF1A, the exact mechanisms about how RASSF1A functions in human cancers were largely unknown. Moreover, the effect of mutated K-Ras gene on the function of RASSF1A is lacking. The aim of this study was to investigate the expression profile and methylation status of RASSF1A gene, and to explore its concrete mechanisms as a tumor suppressor gene in Nasopharyngeal Carcinoma.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Hong Kong 1 3%
Poland 1 3%
Unknown 33 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 23%
Student > Ph. D. Student 7 20%
Student > Master 5 14%
Student > Postgraduate 4 11%
Professor > Associate Professor 2 6%
Other 5 14%
Unknown 4 11%
Readers by discipline Count As %
Medicine and Dentistry 10 29%
Agricultural and Biological Sciences 8 23%
Biochemistry, Genetics and Molecular Biology 8 23%
Immunology and Microbiology 3 9%
Neuroscience 1 3%
Other 0 0%
Unknown 5 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2014.
All research outputs
#17,285,668
of 25,373,627 outputs
Outputs from Journal of Experimental & Clinical Cancer Research
#1,246
of 2,378 outputs
Outputs of similar age
#143,874
of 172,671 outputs
Outputs of similar age from Journal of Experimental & Clinical Cancer Research
#5
of 6 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,378 research outputs from this source. They receive a mean Attention Score of 4.8. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,671 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.