Title |
The Hepatic Response to Thermal Injury: Is the Liver Important for Postburn Outcomes?
|
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Published in |
Molecular Medicine, April 2009
|
DOI | 10.2119/molmed.2009.00005 |
Pubmed ID | |
Authors |
Marc G. Jeschke |
Abstract |
Thermal injury produces a profound hypermetabolic and hypercatabolic stress response characterized by increased endogenous glucose production via gluconeogenesis and glycogenolysis, lipolysis, and proteolysis. The liver is the central body organ involved in these metabolic responses. It is suggested that the liver, with its metabolic, inflammatory, immune, and acute phase functions, plays a pivotal role in patient survival and recovery by modulating multiple pathways following thermal injury. Studies have evaluated the role and function of the liver during the postburn response and showed that liver integrity and function are essential for survival, and that hepatic acute phase proteins are strong predictors for postburn survival. This review discusses these studies and delineates the pivotal role of the liver in patients following severe thermal injury. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | <1% |
Unknown | 103 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 13% |
Student > Master | 12 | 12% |
Student > Bachelor | 10 | 10% |
Student > Postgraduate | 9 | 9% |
Student > Ph. D. Student | 8 | 8% |
Other | 19 | 18% |
Unknown | 33 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 27 | 26% |
Agricultural and Biological Sciences | 13 | 13% |
Biochemistry, Genetics and Molecular Biology | 8 | 8% |
Nursing and Health Professions | 7 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
Other | 11 | 11% |
Unknown | 35 | 34% |