Title |
Study on genes of the serotonergic system and suicidal behavior: protocol for a case–control study in Mexican population
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Published in |
BMC Psychiatry, February 2014
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DOI | 10.1186/1471-244x-14-29 |
Pubmed ID | |
Authors |
Carlos Alfonso Tovilla-Zárate, Thelma Beatriz González-Castro, Isela Juárez-Rojop, Sherezada Pool García, Martha Patricia Velázquez-Sánchez, Mario Villar-Soto, Alma Genis, Humberto Nicolini, María Lilia López-Narváez, María Antonia Jiménez-Santos |
Abstract |
Suicidal behavior is a leading cause of injury and death worldwide. Several studies have provided a possible relationship between genetic factors and suicidal behavior. Also, these studies have shown evidence for altered serotonergic neural transmission in the pathogenesis of suicidal behavior. In addition, genes pertaining to the serotonergic system have been proposed as candidates to establish biological correlates between suicidal behavior and the serotonergic system. The most studied genes are SCL6A4, HTR2A, HTR2C, HTR1A, HTR1B, TPH-1, and TPH-2. To get a comprehensive understanding of the association with suicidal behavior we will conduct genotype assays studies in a Mexican population. |
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Other | 8 | 14% |
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