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Mendeley readers
| Title |
Asthma: Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene as risk factors
|
|---|---|
| Published in |
Allergy, Asthma & Clinical Immunology, February 2014
|
| DOI | 10.1186/1710-1492-10-8 |
| Pubmed ID | |
| Authors |
Ana Carolina Zimiani de Paiva, Fernando Augusto de Lima Marson, José Dirceu Ribeiro, Carmen Sílvia Bertuzzo |
| Abstract |
Asthma is caused by both environmental and genetic factors. The ADRB2 gene, which encodes the beta 2-adrenergic receptor, is one of the most extensively studied genes with respect to asthma prevalence and severity. The Arg16Gly (+46A > G) and Gln27Glu (+79C > G) polymorphisms in the ADRB2 gene cause changes in the amino acids flanking the receptor ligand site, altering the response to bronchodilators and the risk of asthma through complex pathways. The ADRB2 polymorphisms affect beta-adrenergic bronchodilator action and are a tool to identify at-risk populations. |
Mendeley readers
The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 65 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 16 | 24% |
| Student > Master | 16 | 24% |
| Researcher | 10 | 15% |
| Student > Ph. D. Student | 9 | 13% |
| Student > Doctoral Student | 3 | 4% |
| Other | 6 | 9% |
| Unknown | 7 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 21% |
| Pharmacology, Toxicology and Pharmaceutical Science | 12 | 18% |
| Biochemistry, Genetics and Molecular Biology | 11 | 16% |
| Agricultural and Biological Sciences | 9 | 13% |
| Sports and Recreations | 3 | 4% |
| Other | 6 | 9% |
| Unknown | 12 | 18% |