Title |
Establishment of monoclonal anti-human CD26 antibodies suitable for immunostaining of formalin-fixed tissue
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Published in |
Diagnostic Pathology, February 2014
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DOI | 10.1186/1746-1596-9-30 |
Pubmed ID | |
Authors |
Ryo Hatano, Taketo Yamada, Shuji Matsuoka, Satoshi Iwata, Hiroto Yamazaki, Eriko Komiya, Toshihiro Okamoto, Nam H Dang, Kei Ohnuma, Chikao Morimoto |
Abstract |
A T cell costimulatory molecule with dipeptidyl peptidase IV (DPPIV) activity in its extracellular region, CD26 is a multifunctional molecule associated with various proteins such as adenosine deaminase, caveolin-1, CXCR4, collagen, and fibronectin, while playing an important role in the regulation of inflammatory responses and tumor biology. We have focused on CD26 as a novel therapeutic target for various tumors and immune disorders, and have developed a humanized anti-CD26 monoclonal antibody (mAb), YS110, which is currently being evaluated in a phase I clinical trial for patients with CD26-expressing tumors, including malignant mesothelioma. Since detection of tumor CD26 expression is required for determining potential eligibility for YS110 therapy, the development of anti-human CD26 mAb that can clearly and reliably detect the denatured CD26 molecule in the formalin-fixed paraffin-embedded tissues is critical. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 19 | 100% |
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Researcher | 4 | 21% |
Student > Master | 4 | 21% |
Other | 3 | 16% |
Professor > Associate Professor | 2 | 11% |
Student > Bachelor | 1 | 5% |
Other | 1 | 5% |
Unknown | 4 | 21% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Psychology | 2 | 11% |
Veterinary Science and Veterinary Medicine | 1 | 5% |
Other | 1 | 5% |
Unknown | 6 | 32% |