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Attention Score in Context
| Title |
Hyperlipidemic microenvironment conditionates damage mechanisms in human chondrocytes by oxidative stress
|
|---|---|
| Published in |
Lipids in Health and Disease, June 2017
|
| DOI | 10.1186/s12944-017-0510-x |
| Pubmed ID | |
| Authors |
Daniel Medina-Luna, Mónica Guadalupe Santamaría-Olmedo, Yessica Zamudio-Cuevas, Karina Martínez-Flores, Javier Fernández-Torres, Gabriela Angélica Martínez-Nava, Denise Clavijo-Cornejo, Cristina Hernández-Díaz, Anell Olivos-Meza, Luis Enrique Gomez-Quiroz, María Concepción Gutiérrez-Ruiz, Carlos Pineda, Francisco Blanco, Anthony M. Reginato, Alberto López-Reyes |
| Abstract |
Currently, two pathogenic pathways describe the role of obesity in osteoarthritis (OA); one through biomechanical stress, and the other by the contribution of systemic inflammation. The aim of this study was to evaluate the effect of free fatty acids (FFA) in human chondrocytes (HC) expression of proinflammatory factors and reactive oxygen species (ROS). HC were exposed to two different concentrations of FFA in order to evaluate the secretion of adipokines through cytokines immunoassays panel, quantify the protein secretion of FFA-treated chondrocytes, and fluorescent cytometry assays were performed to evaluate the reactive oxygen species (ROS) production. HC injury was observed at 48 h of treatment with FFA. In the FFA-treated HC the production of reactive oxygen species such as superoxide radical, hydrogen peroxide, and the reactive nitrogen species increased significantly in a at the two-dose tested (250 and 500 μM). In addition, we found an increase in the cytokine secretion of IL-6 and chemokine IL-8 in FFA-treated HC in comparison to the untreated HC. In our in vitro model of HC, a hyperlipidemia microenvironment induces an oxidative stress state that enhances the inflammatory process mediated by adipokines secretion in HC. |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 6 | 17% |
| Other | 5 | 14% |
| Student > Master | 5 | 14% |
| Researcher | 4 | 11% |
| Student > Ph. D. Student | 3 | 8% |
| Other | 6 | 17% |
| Unknown | 7 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 31% |
| Biochemistry, Genetics and Molecular Biology | 8 | 22% |
| Agricultural and Biological Sciences | 2 | 6% |
| Unspecified | 2 | 6% |
| Chemistry | 2 | 6% |
| Other | 4 | 11% |
| Unknown | 7 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2017.
All research outputs
#20,427,593
of 22,979,862 outputs
Outputs from Lipids in Health and Disease
#1,209
of 1,457 outputs
Outputs of similar age
#276,107
of 317,411 outputs
Outputs of similar age from Lipids in Health and Disease
#26
of 34 outputs
Altmetric has tracked 22,979,862 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,457 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,411 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.