Title |
Sildenafil ameliorates oxidative stress and DNA damage in the stenotic kidneys in mice with renovascular hypertension
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Published in |
Journal of Translational Medicine, February 2014
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DOI | 10.1186/1479-5876-12-35 |
Pubmed ID | |
Authors |
Ananda T Dias, Bianca P Rodrigues, Marcella L Porto, Agata L Gava, Camille M Balarini, Flavia P S Freitas, Zaira Palomino, Dulce E Casarini, Bianca P Campagnaro, Thiago M C Pereira, Silvana S Meyrelles, Elisardo C Vasquez |
Abstract |
Oxidative stress and DNA damage have been implicated in the pathogenesis of renovascular hypertension induced by renal artery stenosis in the two-kidney, one-clip (2K1C) Goldblatt model. Considering our previous report indicating that the chronic blockade of phosphodiesterase 5 with sildenafil (Viagra) has marked beneficial effects on oxidative stress and DNA damage, we tested the hypothesis that sildenafil could also protect the stenotic kidneys of 2K1C hypertensive mice against oxidative stress and genotoxicity. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Korea, Republic of | 1 | 2% |
Unknown | 49 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 7 | 14% |
Student > Bachelor | 5 | 10% |
Student > Ph. D. Student | 4 | 8% |
Other | 3 | 6% |
Student > Doctoral Student | 3 | 6% |
Other | 14 | 28% |
Unknown | 14 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 24% |
Medicine and Dentistry | 9 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 10% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Neuroscience | 2 | 4% |
Other | 5 | 10% |
Unknown | 14 | 28% |