Title |
Combined PD-1 blockade and GITR triggering induce a potent antitumor immunity in murine cancer models and synergizes with chemotherapeutic drugs
|
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Published in |
Journal of Translational Medicine, February 2014
|
DOI | 10.1186/1479-5876-12-36 |
Pubmed ID | |
Authors |
Lei Lu, Xiaobing Xu, Bin Zhang, Rongsheng Zhang, Hongzan Ji, Xuan Wang |
Abstract |
The coinhibitory receptor Programmed Death-1 (PD-1) inhibits effector functions of activated T cells and prevents autoimmunity, however, cancer hijack this pathway to escape from immune attack. The costimulatory receptor glucocorticoid-induced TNFR related protein (GITR) is up-regulated on activated T cells and increases their proliferation, activation and cytokine production. We hypothesize that concomitant PD-1 blockade and GITR triggering would synergistically improve the effector functions of tumor-infiltrating T cells and increase the antitumor immunity. In present study, we evaluated the antitumor effects and mechanisms of combined PD-1 blockade and GITR triggering in a clinically highly relevant murine ID8 ovarian cancer model. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 2% |
France | 1 | <1% |
Netherlands | 1 | <1% |
Belgium | 1 | <1% |
Uruguay | 1 | <1% |
Unknown | 190 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 54 | 27% |
Student > Ph. D. Student | 38 | 19% |
Student > Master | 22 | 11% |
Other | 18 | 9% |
Student > Bachelor | 13 | 7% |
Other | 25 | 13% |
Unknown | 27 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 50 | 25% |
Medicine and Dentistry | 48 | 24% |
Biochemistry, Genetics and Molecular Biology | 22 | 11% |
Immunology and Microbiology | 22 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
Other | 17 | 9% |
Unknown | 32 | 16% |