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Imepitoin is well tolerated in healthy and epileptic cats

Overview of attention for article published in BMC Veterinary Research, June 2017
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Title
Imepitoin is well tolerated in healthy and epileptic cats
Published in
BMC Veterinary Research, June 2017
DOI 10.1186/s12917-017-1087-3
Pubmed ID
Authors

Odilo Engel, Thilo von Klopmann, Arianna Maiolini, Jessica Freundt-Revilla, Andrea Tipold

Abstract

Epilepsy in the cat is a serious medical condition. To date there are no licensed treatments for feline epilepsy and no well-controlled clinical studies on the efficacy or safety of antiepileptic drugs in cats. The aim of this study was to collect tolerability data and first exploratory efficacy data of imepitoin in both healthy and epileptic cats. In two tolerability studies, 30 healthy cats received imepition twice daily in doses of 0, 30, 40 or 80 mg/kg bodyweight for 30 days. No serious adverse events were observed in any of the dose groups. In the imepitoin treated groups, emesis was observed in some animals temporarily and intermittently mainly in the second and third weeks of treatment. In a small, single-arm, open label, uncontrolled clinical trial eight cats suffering from idiopathic epilepsy were treated with imepitoin twice daily at doses of 30 mg/kg bodyweight for 30 days. Four of these cats (50%) achieved seizure freedom for at least 8 weeks under treatment. Adverse events, mostly lethargy, decreased appetite and emesis, were often mild and transient. In summary, imepitoin was well tolerated in healthy and epileptic cats and showed in a pilot trial indication for efficacy in treating feline epilepsy.

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X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Unknown 73 99%

Demographic breakdown

Readers by professional status Count As %
Other 10 14%
Student > Master 8 11%
Researcher 7 9%
Lecturer 5 7%
Student > Bachelor 5 7%
Other 14 19%
Unknown 25 34%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 34 46%
Medicine and Dentistry 4 5%
Agricultural and Biological Sciences 3 4%
Business, Management and Accounting 2 3%
Biochemistry, Genetics and Molecular Biology 1 1%
Other 2 3%
Unknown 28 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2017.
All research outputs
#14,164,510
of 24,393,299 outputs
Outputs from BMC Veterinary Research
#903
of 3,161 outputs
Outputs of similar age
#159,509
of 321,277 outputs
Outputs of similar age from BMC Veterinary Research
#38
of 89 outputs
Altmetric has tracked 24,393,299 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,161 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,277 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.