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Toll like Receptor (TLR)-4 as a Regulator of Peripheral Endogenous Opioid-Mediated Analgesia in Inflammation

Overview of attention for article published in Molecular Pain, January 2014
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Title
Toll like Receptor (TLR)-4 as a Regulator of Peripheral Endogenous Opioid-Mediated Analgesia in Inflammation
Published in
Molecular Pain, January 2014
DOI 10.1186/1744-8069-10-10
Pubmed ID
Authors

Reine-Solange Sauer, Dagmar Hackel, Laura Morschel, Henrike Sahlbach, Ying Wang, Shaaban A Mousa, Norbert Roewer, Alexander Brack, Heike L Rittner

Abstract

Leukocytes containing opioid peptides locally control inflammatory pain. In the early phase of complete Freund's adjuvant (CFA)-induced hind paw inflammation, formyl peptides (derived e.g. from Mycobacterium butyricum) trigger the release of opioid peptides from neutrophils contributing to tonic basal antinociception. In the later phase we hypothesized that toll-like-receptor-(TLR)-4 activation of monocytes/macrophages triggers opioid peptide release and thereby stimulates peripheral opioid-dependent antinociception.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Japan 1 1%
United States 1 1%
Ukraine 1 1%
Unknown 81 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 16 19%
Student > Master 15 18%
Student > Ph. D. Student 14 16%
Researcher 11 13%
Student > Doctoral Student 5 6%
Other 14 16%
Unknown 10 12%
Readers by discipline Count As %
Medicine and Dentistry 20 24%
Agricultural and Biological Sciences 13 15%
Neuroscience 13 15%
Immunology and Microbiology 10 12%
Biochemistry, Genetics and Molecular Biology 7 8%
Other 9 11%
Unknown 13 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 February 2014.
All research outputs
#20,655,488
of 25,373,627 outputs
Outputs from Molecular Pain
#477
of 669 outputs
Outputs of similar age
#243,184
of 319,271 outputs
Outputs of similar age from Molecular Pain
#35
of 58 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 319,271 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.