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Age differences in the impact of forced swimming test on serotonin transporter levels in lateral septum and dorsal raphe

Overview of attention for article published in Behavioral and Brain Functions, February 2014
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Title
Age differences in the impact of forced swimming test on serotonin transporter levels in lateral septum and dorsal raphe
Published in
Behavioral and Brain Functions, February 2014
DOI 10.1186/1744-9081-10-3
Pubmed ID
Authors

Rosa-Elena Ulloa, Aliyeri Díaz-Valderrama, Jaime Herrera-Pérez, Martha León-Olea, Lucía Martínez-Mota

Abstract

Forced swimming test (FST) is an animal model which evaluates behavioral despair and the effect of antidepressants such as the selective serotonin reuptake inhibitors; the FST modifies the expression of some receptors related to antidepressant response, but it is not known whether serotonin transporter (SERT), their main target, is affected by this test in animals of different ages. Antidepressant response has shown age-dependent variations which could be associated with SERT expression. The aim of the present study was to analyze changes in the SERT immunoreactivity (SERT-IR) in dorsal raphe and lateral septum of male rats from different age groups with or without behavioral despair induced by their exposure to the FST, since these two structures are related to the expression of this behavior.

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Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 2%
United States 1 2%
Argentina 1 2%
Unknown 46 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 18%
Student > Master 8 16%
Researcher 5 10%
Student > Doctoral Student 4 8%
Student > Bachelor 4 8%
Other 11 22%
Unknown 8 16%
Readers by discipline Count As %
Neuroscience 13 27%
Agricultural and Biological Sciences 5 10%
Biochemistry, Genetics and Molecular Biology 4 8%
Psychology 2 4%
Medicine and Dentistry 2 4%
Other 9 18%
Unknown 14 29%