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Wogonin suppresses stem cell-like traits of CD133 positive osteosarcoma cell via inhibiting matrix metallopeptidase-9 expression

Overview of attention for article published in BMC Complementary and Alternative Medicine, June 2017
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Title
Wogonin suppresses stem cell-like traits of CD133 positive osteosarcoma cell via inhibiting matrix metallopeptidase-9 expression
Published in
BMC Complementary and Alternative Medicine, June 2017
DOI 10.1186/s12906-017-1788-y
Pubmed ID
Authors

Do Luong Huynh, Taeho Kwon, Jiao Jiao Zhang, Neelesh Sharma, Meeta Gera, Mrinmoy Ghosh, Nameun Kim, Somi Kim Cho, Dong Sun Lee, Yang Ho Park, Dong Kee Jeong

Abstract

Several efforts have been deployed to cure osteosarcoma, a high-grade malignant bone tumour in children and adolescents. However, some challenges such as drug resistance, relapse, and tumour metastasis remain owing to the existence of cancer stem cells (CSC). There is an urgent need to develop cost-effective and safe therapies. Wogonin, an extract from the root of Scutellaria baicalensis, has long been considered as a promising natural and safe compound for anti-tumourigenesis, particularly to inhibit tumour invasion and metastasis. Hoechst 33,342 staining, wound healing assay, sphere formation assay, western blotting, and gelatin zymography assays were performed in CD133 positive osteosarcoma cell. In this study, we examined the effect of Wogonin on the mobility of human osteosarcoma CSC. Wogonin induces apoptosis of human osteosarcoma CSC, inhibits its mobility in vitro via downregulation of MMP-9 expression, and represses its renewal ability. We demonstrated that Wogonin decreases the renewal capacity of CSC. By inhibiting the formation of and reducing the size of spheres, Wogonin at a concentration of 40-80 μM effectively minimizes potential risk from CSC. Taken together, we have demonstrated a new approach for developing a potential therapy for osteosarcoma.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 24%
Other 2 10%
Researcher 2 10%
Student > Postgraduate 2 10%
Student > Bachelor 1 5%
Other 5 24%
Unknown 4 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 24%
Medicine and Dentistry 3 14%
Unspecified 1 5%
Agricultural and Biological Sciences 1 5%
Veterinary Science and Veterinary Medicine 1 5%
Other 4 19%
Unknown 6 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2017.
All research outputs
#9,102,967
of 11,370,524 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,649
of 2,363 outputs
Outputs of similar age
#192,008
of 266,599 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#20
of 26 outputs
Altmetric has tracked 11,370,524 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,363 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,599 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.