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Gene expression profiling of mesenteric lymph nodes from sheep with natural scrapie

Overview of attention for article published in BMC Genomics, January 2014
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Title
Gene expression profiling of mesenteric lymph nodes from sheep with natural scrapie
Published in
BMC Genomics, January 2014
DOI 10.1186/1471-2164-15-59
Pubmed ID
Authors

Hicham Filali, Inmaculada Martín-Burriel, Frank Harders, Luis Varona, Carlos Hedman, Diego R Mediano, Marta Monzón, Alex Bossers, Juan J Badiola, Rosa Bolea

Abstract

Prion diseases are characterized by the accumulation of the pathogenic PrPSc protein, mainly in the brain and the lymphoreticular system. Although prions multiply/accumulate in the lymph nodes without any detectable pathology, transcriptional changes in this tissue may reflect biological processes that contribute to the molecular pathogenesis of prion diseases. Little is known about the molecular processes that occur in the lymphoreticular system in early and late stages of prion disease. We performed a microarray-based study to identify genes that are differentially expressed at different disease stages in the mesenteric lymph node of sheep naturally infected with scrapie. Oligo DNA microarrays were used to identify gene-expression profiles in the early/middle (preclinical) and late (clinical) stages of the disease.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 36 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 27%
Student > Bachelor 6 16%
Professor 5 14%
Student > Ph. D. Student 5 14%
Student > Doctoral Student 2 5%
Other 3 8%
Unknown 6 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 30%
Biochemistry, Genetics and Molecular Biology 8 22%
Medicine and Dentistry 4 11%
Veterinary Science and Veterinary Medicine 3 8%
Immunology and Microbiology 1 3%
Other 2 5%
Unknown 8 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 February 2014.
All research outputs
#15,293,290
of 22,743,667 outputs
Outputs from BMC Genomics
#6,670
of 10,633 outputs
Outputs of similar age
#188,716
of 305,720 outputs
Outputs of similar age from BMC Genomics
#276
of 441 outputs
Altmetric has tracked 22,743,667 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,633 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,720 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 441 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.