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The role of cullin4B in human cancers

Overview of attention for article published in Experimental Hematology & Oncology, June 2017
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Title
The role of cullin4B in human cancers
Published in
Experimental Hematology & Oncology, June 2017
DOI 10.1186/s40164-017-0077-2
Pubmed ID
Authors

Ying Li, Xin Wang

Abstract

Cullin 4B (CUL4B) is a scaffold of the Cullin4B-Ring E3 ligase complex (CRL4B) that plays an important role in proteolysis and is implicated in tumorigenesis. Aberrant expression of CUL4B has been reported in various types of human diseases. Recently, studies have shown that CUL4B was overexpressed in a multitude of solid neoplasms and affect the expression of several tumor suppressor genes. In this review, we aim to summarize the biological function of CUL4B in order to better understand its pathogenesis in human cancers.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 33%
Student > Bachelor 5 28%
Researcher 2 11%
Lecturer 1 6%
Unknown 4 22%
Readers by discipline Count As %
Medicine and Dentistry 9 50%
Biochemistry, Genetics and Molecular Biology 4 22%
Environmental Science 1 6%
Unknown 4 22%