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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Protein signatures of oxidative stress response in a patient specific cell line model for autism
|
|---|---|
| Published in |
Molecular Autism, February 2014
|
| DOI | 10.1186/2040-2392-5-10 |
| Pubmed ID | |
| Authors |
Andreas G Chiocchetti, Denise Haslinger, Maximilian Boesch, Thomas Karl, Stefan Wiemann, Christine M Freitag, Fritz Poustka, Burghardt Scheibe, Johann W Bauer, Helmut Hintner, Michael Breitenbach, Josef Kellermann, Friedrich Lottspeich, Sabine M Klauck, Lore Breitenbach-Koller |
| Abstract |
Known genetic variants can account for 10% to 20% of all cases with autism spectrum disorders (ASD). Overlapping cellular pathomechanisms common to neurons of the central nervous system (CNS) and in tissues of peripheral organs, such as immune dysregulation, oxidative stress and dysfunctions in mitochondrial and protein synthesis metabolism, were suggested to support the wide spectrum of ASD on unifying disease phenotype. Here, we studied in patient-derived lymphoblastoid cell lines (LCLs) how an ASD-specific mutation in ribosomal protein RPL10 (RPL10[H213Q]) generates a distinct protein signature. We compared the RPL10[H213Q] expression pattern to expression patterns derived from unrelated ASD patients without RPL10[H213Q] mutation. In addition, a yeast rpl10 deficiency model served in a proof-of-principle study to test for alterations in protein patterns in response to oxidative stress. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| United Kingdom | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
| Science communicators (journalists, bloggers, editors) | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Austria | 1 | 2% |
| Unknown | 63 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 15 | 23% |
| Student > Ph. D. Student | 11 | 17% |
| Student > Master | 10 | 15% |
| Student > Doctoral Student | 4 | 6% |
| Student > Postgraduate | 4 | 6% |
| Other | 14 | 22% |
| Unknown | 7 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 23% |
| Agricultural and Biological Sciences | 15 | 23% |
| Psychology | 8 | 12% |
| Medicine and Dentistry | 5 | 8% |
| Neuroscience | 3 | 5% |
| Other | 8 | 12% |
| Unknown | 11 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2014.
All research outputs
#13,402,674
of 22,743,667 outputs
Outputs from Molecular Autism
#554
of 664 outputs
Outputs of similar age
#164,161
of 311,648 outputs
Outputs of similar age from Molecular Autism
#32
of 35 outputs
Altmetric has tracked 22,743,667 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 664 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.4. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,648 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.