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Engrailed2 modulates cerebellar granule neuron precursor proliferation, differentiation and insulin-like growth factor 1 signaling during postnatal development

Overview of attention for article published in Molecular Autism, February 2014
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Mentioned by

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3 X users
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1 peer review site

Citations

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20 Dimensions

Readers on

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37 Mendeley
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Title
Engrailed2 modulates cerebellar granule neuron precursor proliferation, differentiation and insulin-like growth factor 1 signaling during postnatal development
Published in
Molecular Autism, February 2014
DOI 10.1186/2040-2392-5-9
Pubmed ID
Authors

Ian T Rossman, Lulu Lin, Katherine M Morgan, Marissa DiGiovine, Elise K Van Buskirk, Silky Kamdar, James H Millonig, Emanuel DiCicco-Bloom

Abstract

The homeobox transcription factor Engrailed2 (En2) has been studied extensively in neurodevelopment, particularly in the midbrain/hindbrain region and cerebellum, where it exhibits dynamic patterns of expression and regulates cell patterning and morphogenesis. Because of its roles in regulating cerebellar development and evidence of cerebellar pathology in autism spectrum disorder (ASD), we previously examined an ENGRAILED2 association and found evidence to support EN2 as a susceptibility gene, a finding replicated by several other investigators. However, its functions at the cell biological level remain undefined. In the mouse, En2 gene is expressed in granule neuron precursors (GNPs) just as they exit the cell cycle and begin to differentiate, raising the possibility that En2 may modulate these developmental processes.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 30%
Researcher 6 16%
Student > Postgraduate 4 11%
Student > Master 4 11%
Student > Doctoral Student 3 8%
Other 5 14%
Unknown 4 11%
Readers by discipline Count As %
Neuroscience 9 24%
Agricultural and Biological Sciences 9 24%
Medicine and Dentistry 3 8%
Psychology 3 8%
Computer Science 2 5%
Other 5 14%
Unknown 6 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2016.
All research outputs
#12,893,599
of 22,743,667 outputs
Outputs from Molecular Autism
#518
of 664 outputs
Outputs of similar age
#155,313
of 307,209 outputs
Outputs of similar age from Molecular Autism
#25
of 35 outputs
Altmetric has tracked 22,743,667 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 664 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.4. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,209 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.