Title |
Impact of heterozygote CFTR Mutations in COPD patients with Chronic Bronchitis
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Published in |
Respiratory Research, February 2014
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DOI | 10.1186/1465-9921-15-18 |
Pubmed ID | |
Authors |
S Vamsee Raju, Jody H Tate, Sandra KG Peacock, Ping Fang, Robert A Oster, Mark T Dransfield, Steven M Rowe |
Abstract |
Cigarette smoking causes Chronic Obstructive Pulmonary Disease (COPD), the 3rd leading cause of death in the U.S. CFTR ion transport dysfunction has been implicated in COPD pathogenesis, and is associated with chronic bronchitis. However, susceptibility to smoke induced lung injury is variable and the underlying genetic contributors remain unclear. We hypothesized that presence of CFTR mutation heterozygosity may alter susceptibility to cigarette smoke induced CFTR dysfunction. Consequently, COPD patients with chronic bronchitis may have a higher rate of CFTR mutations compared to the general population. |
X Demographics
Geographical breakdown
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United Kingdom | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 51 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 11 | 22% |
Researcher | 6 | 12% |
Student > Ph. D. Student | 5 | 10% |
Student > Bachelor | 4 | 8% |
Other | 4 | 8% |
Other | 13 | 25% |
Unknown | 8 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 16 | 31% |
Biochemistry, Genetics and Molecular Biology | 6 | 12% |
Agricultural and Biological Sciences | 6 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 10% |
Nursing and Health Professions | 2 | 4% |
Other | 5 | 10% |
Unknown | 11 | 22% |