Title |
Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production
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Published in |
BMC Research Notes, June 2017
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DOI | 10.1186/s13104-017-2512-1 |
Pubmed ID | |
Authors |
Subhash Dhital, Jeevan Bahadur Sherchand, Bharat Mani Pokharel, Keshab Parajuli, Shyam Kumar Mishra, Sangita Sharma, Hari Prasad Kattel, Sundar Khadka, Sulochana Khatiwada, Basista Rijal |
Abstract |
Shigella is an important cause of bacterial gastroenteritis in resource-poor countries. The treatment of shigellosis mostly requires antibiotics. However, the increase of multidrug resistance along with emergence of extended-spectrum β-lactamase and ciprofloxacin resistance among Shigella spp. has challenged the situation. This study was conducted to determine the distribution of species and antibiotic susceptibility pattern of Shigella species isolated from stool specimen among children less than 5 years of age in Nepal. Out of total 717 stool samples collected, 15 cases of Shigella spp. was isolated which includes 12 S. flexneri and 3 S. sonnei. Multidrug resistance was found among 13(86%) of the isolates. One of the isolates of S. flexneri was found to be ESBL-producer with MIC >256 mg/L for cefixime. The high occurrence of multidrug resistance among Shigella spp. along with a case of ESBL-production for the first time in Nepal alarms the concerns about dissemination of the resistant isolates. So, systemic monitoring of the antimicrobial susceptibility pattern of Shigella spp. is becoming crucial to guide therapy. |
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Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 49 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 20% |
Student > Ph. D. Student | 7 | 14% |
Student > Master | 5 | 10% |
Student > Doctoral Student | 4 | 8% |
Lecturer > Senior Lecturer | 4 | 8% |
Other | 6 | 12% |
Unknown | 13 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 11 | 22% |
Immunology and Microbiology | 6 | 12% |
Biochemistry, Genetics and Molecular Biology | 5 | 10% |
Nursing and Health Professions | 4 | 8% |
Agricultural and Biological Sciences | 3 | 6% |
Other | 6 | 12% |
Unknown | 14 | 29% |