A rare case of poorly differentiated thyroid carcinoma probably arising from a nodular goiter

Hironao Yasuoka, Yasushi Nakamura, Mitsuyoshi Hirokawa, Ken-ichi Yoshida, Kana Anno, Masayuki Tori, Masahiko Tsujimoto

Some poorly differentiated thyroid carcinomas (PDTC) arise from pre-existing, well-differentiated carcinomas of follicular cell origin; however, others most likely arise de novo. The case of a PDTC adjacent to a pre-existing nodular goiter is very rare. A patient had a PDTC, a widely invasive, cellular tumor with cells that lacked the nuclear features of a papillary thyroid carcinoma. Carcinoma cells were arranged in trabecular, solid, and microfollicular histological patterns and displayed high mitotic activity. A nodule partially encapsulated in a thick fibrous capsule was found adjacent to the PDTC. The nodule was composed of small or dilated follicles, without papillary carcinoma-like nuclear features, that were consistent with a nodular goiter. The PDTC showed a high Ki-67 labeling index and an NRAS gene mutation (codon 61, Q61K). These results support our diagnosis of a PDTC, probably arising from a nodular goiter.