Title |
Effects of omega-3 polyunsaturated fatty acid supplementation in patients with chronic chagasic cardiomyopathy: study protocol for a randomized controlled trial
|
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Published in |
Trials, November 2013
|
DOI | 10.1186/1745-6215-14-379 |
Pubmed ID | |
Authors |
Paula S Silva, Gilberto Marcelo Sperandio da Silva, Andréa P de Souza, Claudia SA Cardoso, Cristiane A Fonseca, Patricia D Brito, Roberto M Saraiva, Pedro EA Brasil, Roberta O Pinheiro, Alejandro M Hasslocher-Moreno, Sérgio S Xavier, Andréa S Sousa |
Abstract |
Chronic chagasic cardiomyopathy is an inflammatory disease that occurs in approximately 30% of patients infected by the protozoan Trypanosoma cruzi, and it has a profile of high morbidity and mortality. The worst prognosis and the progression of this cardiomyopathy are associated with an exacerbated immune response and the production of proinflammatory cytokines, which also occur in other cardiomyopathies. Some nutrients, including omega-3 polyunsaturated fatty acids (PUFAs), promote the inhibition and/or stimulation of cytokine production. The objective of this trial is to study the effects of omega-3 PUFA supplementation on the inflammatory response and lipid profile in patients with chronic chagasic cardiomyopathy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Malaysia | 1 | <1% |
Indonesia | 1 | <1% |
United Kingdom | 1 | <1% |
Canada | 1 | <1% |
Spain | 1 | <1% |
Unknown | 167 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 28 | 16% |
Student > Bachelor | 26 | 15% |
Researcher | 21 | 12% |
Student > Ph. D. Student | 11 | 6% |
Other | 10 | 6% |
Other | 33 | 19% |
Unknown | 43 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 50 | 29% |
Nursing and Health Professions | 18 | 10% |
Agricultural and Biological Sciences | 16 | 9% |
Biochemistry, Genetics and Molecular Biology | 6 | 3% |
Immunology and Microbiology | 6 | 3% |
Other | 29 | 17% |
Unknown | 47 | 27% |