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Effects of omega-3 polyunsaturated fatty acid supplementation in patients with chronic chagasic cardiomyopathy: study protocol for a randomized controlled trial

Overview of attention for article published in Trials, November 2013
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Title
Effects of omega-3 polyunsaturated fatty acid supplementation in patients with chronic chagasic cardiomyopathy: study protocol for a randomized controlled trial
Published in
Trials, November 2013
DOI 10.1186/1745-6215-14-379
Pubmed ID
Authors

Paula S Silva, Gilberto Marcelo Sperandio da Silva, Andréa P de Souza, Claudia SA Cardoso, Cristiane A Fonseca, Patricia D Brito, Roberto M Saraiva, Pedro EA Brasil, Roberta O Pinheiro, Alejandro M Hasslocher-Moreno, Sérgio S Xavier, Andréa S Sousa

Abstract

Chronic chagasic cardiomyopathy is an inflammatory disease that occurs in approximately 30% of patients infected by the protozoan Trypanosoma cruzi, and it has a profile of high morbidity and mortality. The worst prognosis and the progression of this cardiomyopathy are associated with an exacerbated immune response and the production of proinflammatory cytokines, which also occur in other cardiomyopathies. Some nutrients, including omega-3 polyunsaturated fatty acids (PUFAs), promote the inhibition and/or stimulation of cytokine production. The objective of this trial is to study the effects of omega-3 PUFA supplementation on the inflammatory response and lipid profile in patients with chronic chagasic cardiomyopathy.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 172 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 <1%
Indonesia 1 <1%
United Kingdom 1 <1%
Canada 1 <1%
Spain 1 <1%
Unknown 167 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 28 16%
Student > Bachelor 26 15%
Researcher 21 12%
Student > Ph. D. Student 11 6%
Other 10 6%
Other 33 19%
Unknown 43 25%
Readers by discipline Count As %
Medicine and Dentistry 50 29%
Nursing and Health Professions 18 10%
Agricultural and Biological Sciences 16 9%
Biochemistry, Genetics and Molecular Biology 6 3%
Immunology and Microbiology 6 3%
Other 29 17%
Unknown 47 27%