Title |
The fraction of varicella zoster virus-specific antibodies among all intrathecally-produced antibodies discriminates between patients with varicella zoster virus reactivation and multiple sclerosis
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Published in |
Fluids and Barriers of the CNS, February 2014
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DOI | 10.1186/2045-8118-11-3 |
Pubmed ID | |
Authors |
Carolin Otto, Jörg Hofmann, Carsten Finke, Mathias Zimmermann, Klemens Ruprecht |
Abstract |
Primary infection with or reactivation of varicella zoster virus (VZV) can cause neurologic complications, which typically result in an intrathecal production of VZV-specific antibodies. Intrathecal antibodies to VZV are detectable by an elevated antibody index (AI). However, elevated VZV AIs are also found in more than half of patients with multiple sclerosis (MS), where they are thought to be part of a polyspecific intrathecal immune response. Determination of the fraction of intrathecally-produced virus-specific antibodies among all intrathecally produced antibodies may discriminate between virus-specific and polyspecific intrathecal immune responses, but the fraction of intrathecally-produced VZV-specific immunoglobulin (Ig)G of the total intrathecally produced IgG (FS anti-VZV) in patients with MS and VZV reactivation has hitherto not been compared. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
United States | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 5% |
South Africa | 1 | 5% |
Brazil | 1 | 5% |
Unknown | 16 | 84% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 16% |
Other | 3 | 16% |
Researcher | 3 | 16% |
Student > Master | 2 | 11% |
Student > Doctoral Student | 1 | 5% |
Other | 4 | 21% |
Unknown | 3 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 10 | 53% |
Neuroscience | 2 | 11% |
Immunology and Microbiology | 1 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Chemistry | 1 | 5% |
Other | 0 | 0% |
Unknown | 4 | 21% |