Title |
Wiring the retinal circuits activated by light during early development
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Published in |
Neural Development, February 2014
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DOI | 10.1186/1749-8104-9-3 |
Pubmed ID | |
Authors |
Gabriel E Bertolesi, Carrie L Hehr, Sarah McFarlane |
Abstract |
Light information is sorted by neuronal circuits to generate image-forming (IF) (interpretation and tracking of visual objects and patterns) and non-image-forming (NIF) tasks. Among the NIF tasks, photic entrainment of circadian rhythms, the pupillary light reflex, and sleep are all associated with physiological responses, mediated mainly by a small group of melanopsin-expressing retinal ganglion cells (mRGCs). Using Xenopus laevis as a model system, and analyzing the c-fos expression induced by light as a surrogate marker of neural activity, we aimed to establish the developmental time at which the cells participating in both systems come on-line in the retina. |
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