Title |
A panel of genes methylated with high frequency in colorectal cancer
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Published in |
BMC Cancer, January 2014
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DOI | 10.1186/1471-2407-14-54 |
Pubmed ID | |
Authors |
Susan M Mitchell, Jason P Ross, Horace R Drew, Thu Ho, Glenn S Brown, Neil FW Saunders, Konsta R Duesing, Michael J Buckley, Rob Dunne, Iain Beetson, Keith N Rand, Aidan McEvoy, Melissa L Thomas, Rohan T Baker, David A Wattchow, Graeme P Young, Trevor J Lockett, Susanne K Pedersen, Lawrence C LaPointe, Peter L Molloy |
Abstract |
The development of colorectal cancer (CRC) is accompanied by extensive epigenetic changes, including frequent regional hypermethylation particularly of gene promoter regions. Specific genes, including SEPT9, VIM1 and TMEFF2 become methylated in a high fraction of cancers and diagnostic assays for detection of cancer-derived methylated DNA sequences in blood and/or fecal samples are being developed. There is considerable potential for the development of new DNA methylation biomarkers or panels to improve the sensitivity and specificity of current cancer detection tests. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 17% |
United Kingdom | 4 | 11% |
Australia | 3 | 8% |
Canada | 1 | 3% |
Switzerland | 1 | 3% |
Unknown | 21 | 58% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 33 | 92% |
Scientists | 3 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 3 | 3% |
United States | 2 | 2% |
United Kingdom | 1 | <1% |
Unknown | 99 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 28 | 27% |
Researcher | 20 | 19% |
Student > Master | 16 | 15% |
Student > Bachelor | 7 | 7% |
Student > Doctoral Student | 7 | 7% |
Other | 12 | 11% |
Unknown | 15 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 33 | 31% |
Biochemistry, Genetics and Molecular Biology | 26 | 25% |
Medicine and Dentistry | 16 | 15% |
Nursing and Health Professions | 2 | 2% |
Computer Science | 2 | 2% |
Other | 7 | 7% |
Unknown | 19 | 18% |