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TRIP-1 via AKT modulation drives lung fibroblast/myofibroblast trans-differentiation

Overview of attention for article published in Respiratory Research, February 2014
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Title
TRIP-1 via AKT modulation drives lung fibroblast/myofibroblast trans-differentiation
Published in
Respiratory Research, February 2014
DOI 10.1186/1465-9921-15-19
Pubmed ID
Authors

Michael F Nyp, Angels Navarro, Mohammad H Rezaiekhaligh, Ricardo E Perez, Sherry M Mabry, Ikechukwu I Ekekezie

Abstract

Myofibroblasts are the critical effector cells in the pathogenesis of pulmonary fibrosis which carries a high degree of morbidity and mortality. We have previously identified Type II TGFβ receptor interacting protein 1 (TRIP-1), through proteomic analysis, as a key regulator of collagen contraction in primary human lung fibroblasts--a functional characteristic of myofibroblasts, and the last, but critical step in the process of fibrosis. However, whether or not TRIP-1 modulates fibroblast trans-differentiation to myofibroblasts is not known.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 27%
Other 2 13%
Student > Bachelor 2 13%
Researcher 2 13%
Student > Ph. D. Student 1 7%
Other 2 13%
Unknown 2 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 20%
Agricultural and Biological Sciences 3 20%
Psychology 2 13%
Chemistry 2 13%
Medicine and Dentistry 2 13%
Other 1 7%
Unknown 2 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2014.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Respiratory Research
#2,958
of 3,062 outputs
Outputs of similar age
#302,300
of 345,137 outputs
Outputs of similar age from Respiratory Research
#36
of 37 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,062 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,137 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.