Title |
Harnessing RNAi nanomedicine for precision therapy
|
---|---|
Published in |
Molecular and Cellular Therapies, February 2014
|
DOI | 10.1186/2052-8426-2-5 |
Pubmed ID | |
Authors |
Dan Peer |
Abstract |
Utilizing RNA interference as an innovative therapeutic strategy has an immense likelihood to generate novel concepts in precision medicine. Several clinical trials are on the way with some positive initial results. Yet, targeting of RNAi payloads such as small interfering RNAs (siRNAs), microRNA (miR) mimetic or anti-miR (antagomirs) into specific cell types remains a challenge. Major attempts are done for developing nano-sized carriers that could overcome systemic, local and cellular barriers. This progress report will focus on the recent advances in the RNAi world, detailing strategies of systemic passive tissue targeting and active cellular targeting, which is often considered as the holy grail of drug delivery. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 12 | 22% |
Student > Ph. D. Student | 10 | 19% |
Student > Master | 8 | 15% |
Student > Bachelor | 6 | 11% |
Student > Doctoral Student | 5 | 9% |
Other | 5 | 9% |
Unknown | 8 | 15% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 13 | 24% |
Chemistry | 7 | 13% |
Biochemistry, Genetics and Molecular Biology | 6 | 11% |
Medicine and Dentistry | 5 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Other | 11 | 20% |
Unknown | 9 | 17% |