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Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23

Overview of attention for article published in BMC Biology, February 2014
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Title
Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23
Published in
BMC Biology, February 2014
DOI 10.1186/1741-7007-12-12
Pubmed ID
Authors

Marilena Ignesti, Marilena Barraco, Gouthami Nallamothu, Julie A Woolworth, Serena Duchi, Giuseppe Gargiulo, Valeria Cavaliere, Tien Hsu

Abstract

The Drosophila abnormal wing discs (awd) belongs to a highly conserved family of genes implicated in metastasis suppression, metabolic homeostasis and epithelial morphogenesis. The cellular function of the mammalian members of this family, the Nm23 proteins, has not yet been clearly defined. Previous awd genetic analyses unraveled its endocytic role that is required for proper internalization of receptors controlling different signaling pathways. In this study, we analyzed the role of Awd in controlling Notch signaling during development.

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Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 4%
Hungary 1 4%
Unknown 24 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 27%
Researcher 5 19%
Student > Master 4 15%
Student > Bachelor 3 12%
Other 1 4%
Other 1 4%
Unknown 5 19%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 35%
Agricultural and Biological Sciences 8 31%
Neuroscience 2 8%
Physics and Astronomy 1 4%
Chemical Engineering 1 4%
Other 0 0%
Unknown 5 19%