Title |
The relationship between mTOR signalling pathway and recombinant antibody productivity in CHO cell lines
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Published in |
BMC Biotechnology, February 2014
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DOI | 10.1186/1472-6750-14-15 |
Pubmed ID | |
Authors |
Raihana Edros, Susan McDonnell, Mohamed Al-Rubeai |
Abstract |
High recombinant protein productivity in mammalian cell lines is often associated with phenotypic changes in protein content, energy metabolism, and cell growth, but the key determinants that regulate productivity are still not clearly understood. The mammalian target of rapamycin (mTOR) signalling pathway has emerged as a central regulator for many cellular processes including cell growth, apoptosis, metabolism, and protein synthesis. This role of this pathway changes in response to diverse environmental cues and allows the upstream proteins that respond directly to extracellular signals (such as nutrient availability, energy status, and physical stresses) to communicate with downstream effectors which, in turn, regulate various essential cellular processes. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 74 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 23% |
Researcher | 16 | 22% |
Student > Master | 8 | 11% |
Student > Bachelor | 8 | 11% |
Student > Doctoral Student | 6 | 8% |
Other | 11 | 15% |
Unknown | 8 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 28 | 38% |
Biochemistry, Genetics and Molecular Biology | 15 | 20% |
Engineering | 8 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Chemical Engineering | 4 | 5% |
Other | 5 | 7% |
Unknown | 10 | 14% |