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Autophagy-lysosome pathway associated neuropathology and axonal degeneration in the brains of alpha-galactosidase A-deficient mice

Overview of attention for article published in Acta Neuropathologica Communications, February 2014
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2 tweeters

Citations

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47 Dimensions

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88 Mendeley
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Title
Autophagy-lysosome pathway associated neuropathology and axonal degeneration in the brains of alpha-galactosidase A-deficient mice
Published in
Acta Neuropathologica Communications, February 2014
DOI 10.1186/2051-5960-2-20
Pubmed ID
Authors

Michael P Nelson, Tonia E Tse, Darrel B O’Quinn, Stefanie M Percival, Edgar A Jaimes, David G Warnock, John J Shacka

Abstract

Mutations in the gene for alpha-galactosidase A result in Fabry disease, a rare, X-linked lysosomal storage disorder characterized by a loss of alpha-galactosidase A enzymatic activity. The resultant accumulation of glycosphingolipids throughout the body leads to widespread vasculopathy with particular detriment to the kidneys, heart and nervous system. Disruption in the autophagy-lysosome pathway has been documented previously in Fabry disease but its relative contribution to nervous system pathology in Fabry disease is unknown. Using an experimental mouse model of Fabry disease, alpha-galactosidase A deficiency, we examined brain pathology in 20-24 month old mice with particular emphasis on the autophagy-lysosome pathway.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 87 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 18%
Student > Master 9 10%
Student > Bachelor 9 10%
Professor > Associate Professor 7 8%
Professor 6 7%
Other 20 23%
Unknown 21 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 20%
Biochemistry, Genetics and Molecular Biology 14 16%
Medicine and Dentistry 10 11%
Neuroscience 10 11%
Chemistry 2 2%
Other 11 13%
Unknown 23 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2022.
All research outputs
#13,718,195
of 21,986,946 outputs
Outputs from Acta Neuropathologica Communications
#1,024
of 1,317 outputs
Outputs of similar age
#105,676
of 200,736 outputs
Outputs of similar age from Acta Neuropathologica Communications
#1
of 1 outputs
Altmetric has tracked 21,986,946 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,317 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 200,736 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them