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Behavioral and transcriptome alterations in male and female mice with postnatal deletion of TrkB in dorsal striatal medium spiny neurons

Overview of attention for article published in Molecular Neurodegeneration, December 2013
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Title
Behavioral and transcriptome alterations in male and female mice with postnatal deletion of TrkB in dorsal striatal medium spiny neurons
Published in
Molecular Neurodegeneration, December 2013
DOI 10.1186/1750-1326-8-47
Pubmed ID
Authors

Ellen M Unterwald, Michelle E Page, Timothy B Brown, Jonathan S Miller, Marta Ruiz, Karen A Pescatore, Baoji Xu, Louis French Reichardt, Joel Beverley, Bin Tang, Heinz Steiner, Elizabeth A Thomas, Michelle E Ehrlich

Abstract

The high affinity tyrosine kinase receptor, TrkB, is the primary receptor for brain derived neurotrophic factor (BDNF) and plays an important role in development, maintenance and plasticity of the striatal output medium size spiny neuron. The striatal BDNF/TrkB system is thereby implicated in many physiologic and pathophysiologic processes, the latter including mood disorders, addiction, and Huntington's disease. We crossed a mouse harboring a transgene directing cre-recombinase expression primarily to postnatal, dorsal striatal medium spiny neurons, to a mouse containing a floxed TrkB allele (fB) mouse designed for deletion of TrkB to determine its role in the adult striatum.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
United Kingdom 1 2%
Unknown 45 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 29%
Student > Ph. D. Student 10 21%
Student > Bachelor 6 13%
Professor 3 6%
Student > Master 3 6%
Other 8 17%
Unknown 4 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 31%
Neuroscience 14 29%
Medicine and Dentistry 5 10%
Psychology 3 6%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 2 4%
Unknown 7 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2014.
All research outputs
#18,365,132
of 22,745,803 outputs
Outputs from Molecular Neurodegeneration
#783
of 845 outputs
Outputs of similar age
#231,084
of 306,864 outputs
Outputs of similar age from Molecular Neurodegeneration
#19
of 20 outputs
Altmetric has tracked 22,745,803 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 845 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 306,864 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.