Title |
Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk
|
---|---|
Published in |
Molecular Neurodegeneration, January 2014
|
DOI | 10.1186/1750-1326-9-2 |
Pubmed ID | |
Authors |
Leon M Tai, Shipra Mehra, Varsha Shete, Steve Estus, G William Rebeck, Guojun Bu, Mary Jo LaDu |
Abstract |
The APOE4 allele of apolipoprotein E (apoE) is the greatest genetic risk factor for Alzheimer's disease (AD) compared to APOE2 and APOE3. Amyloid-β (Aβ), particularly in a soluble oligomeric form (oAβ), is considered a proximal cause of neurodegeneration in AD. Emerging data indicate that levels of soluble oAβ are increased with APOE4, providing a potential mechanism of APOE4-induced AD risk. However, the pathway(s) by which apoE4 may increase oAβ levels are unclear and the subject of continued inquiry. In this editorial review, we present the hypothesis that apoE isoform-specific interactions with Aβ, namely apoE/Aβ complex, modulate Aβ levels. Specifically, we propose that compared to apoE3, apoE4-containing lipoproteins are less lipidated, leading to less stable apoE4/Aβ complexes, resulting in reduced apoE4/Aβ levels and increased accumulation, particularly of oAβ. Evidence that support or counter this argument, as well as the therapeutic significance of this pathway to neurodegeneration, are discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Italy | 1 | <1% |
Unknown | 145 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 38 | 26% |
Researcher | 25 | 17% |
Student > Master | 19 | 13% |
Student > Bachelor | 17 | 12% |
Student > Doctoral Student | 10 | 7% |
Other | 23 | 16% |
Unknown | 15 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 45 | 31% |
Neuroscience | 25 | 17% |
Chemistry | 13 | 9% |
Biochemistry, Genetics and Molecular Biology | 12 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 7% |
Other | 22 | 15% |
Unknown | 20 | 14% |