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Gene expression changes in aging Zebrafish (Danio rerio) brains are sexually dimorphic

Overview of attention for article published in BMC Neuroscience, February 2014
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Title
Gene expression changes in aging Zebrafish (Danio rerio) brains are sexually dimorphic
Published in
BMC Neuroscience, February 2014
DOI 10.1186/1471-2202-15-29
Pubmed ID
Authors

Ayca Arslan-Ergul, Michelle M Adams

Abstract

Brain aging is a multi-factorial process due to both genetic and environmental factors. The zebrafish has recently become a popular model organism for examining aging and age-related diseases because as in humans they age gradually and exhibit cognitive decline. Few studies have examined the biological changes in the aging brain that may contribute to these declines and none have examined them within individuals with respect to gender. Our aim was to identify the main genetic pathways associated with zebrafish brain aging across gender. We chose males and females from specific age groups (young, 7.5-8.5 months and old, 31-36 months) based on the progression of cognitive decline in zebrafish. RNA was isolated from individual brains and subjected to microarray and qPCR analysis. Statistical analyses were performed using a two-way ANOVA and the relevant post-hoc tests.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 86 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 26%
Student > Master 14 16%
Researcher 12 14%
Student > Doctoral Student 11 13%
Student > Bachelor 7 8%
Other 8 9%
Unknown 12 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 26 30%
Agricultural and Biological Sciences 25 29%
Neuroscience 13 15%
Medicine and Dentistry 4 5%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 2 2%
Unknown 14 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2014.
All research outputs
#20,221,866
of 22,745,803 outputs
Outputs from BMC Neuroscience
#1,051
of 1,241 outputs
Outputs of similar age
#192,698
of 223,888 outputs
Outputs of similar age from BMC Neuroscience
#35
of 37 outputs
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So far Altmetric has tracked 1,241 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.