↓ Skip to main content

Genome-wide analysis of DNA methylation in hypothalamus and ovary of Capra hircus

Overview of attention for article published in BMC Genomics, June 2017
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (57th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
7 tweeters

Citations

dimensions_citation
7 Dimensions

Readers on

mendeley
33 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Genome-wide analysis of DNA methylation in hypothalamus and ovary of Capra hircus
Published in
BMC Genomics, June 2017
DOI 10.1186/s12864-017-3866-4
Pubmed ID
Authors

Stefano Frattini, Emanuele Capra, Barbara Lazzari, Stephanie D. McKay, Beatrice Coizet, Andrea Talenti, Debora Groppetti, Pietro Riccaboni, Alessandro Pecile, Stefania Chessa, Bianca Castiglioni, John L. Williams, Giulio Pagnacco, Alessandra Stella, Paola Crepaldi

Abstract

DNA methylation is a frequently studied epigenetic modification due to its role in regulating gene expression and hence in biological processes and in determining phenotypic plasticity in organisms. Rudimentary DNA methylation patterns for some livestock species are publically available: among these, goat methylome deserves to be further explored. Genome-wide DNA methylation maps of the hypothalamus and ovary from Saanen goats were generated using Methyl-CpG binding domain protein sequencing (MBD-seq). Analysis of DNA methylation patterns indicate that the majority of methylation peaks found within genes are located gene body regions, for both organs. Analysis of the distribution of methylated sites per chromosome showed that chromosome X had the lowest number of methylation peaks. The X chromosome has one of the highest percentages of methylated CpG islands in both organs, and approximately 50% of the CpG islands in the goat epigenome are methylated in hypothalamus and ovary. Organ-specific Differentially Methylated Genes (DMGs) were correlated with the expression levels. The comparison between transcriptome and methylome in hypothalamus and ovary showed that a higher level of methylation is not accompanied by a higher gene suppression. The genome-wide DNA methylation map for two goat organs produced here is a valuable starting point for studying the involvement of epigenetic modifications in regulating goat reproduction performance.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 24%
Student > Master 6 18%
Student > Doctoral Student 2 6%
Student > Ph. D. Student 2 6%
Student > Postgraduate 2 6%
Other 6 18%
Unknown 7 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 39%
Biochemistry, Genetics and Molecular Biology 7 21%
Veterinary Science and Veterinary Medicine 2 6%
Engineering 2 6%
Neuroscience 1 3%
Other 1 3%
Unknown 7 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2018.
All research outputs
#7,287,435
of 13,786,654 outputs
Outputs from BMC Genomics
#3,469
of 8,020 outputs
Outputs of similar age
#110,569
of 265,254 outputs
Outputs of similar age from BMC Genomics
#3
of 5 outputs
Altmetric has tracked 13,786,654 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,020 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,254 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.