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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128
|
|---|---|
| Published in |
Molecular Cancer, February 2014
|
| DOI | 10.1186/1476-4598-13-33 |
| Pubmed ID | |
| Authors |
Yogita K Adlakha, Neeru Saini |
| Abstract |
MicroRNAs, the non-coding single-stranded RNA of 19-25 nucleotides are emerging as robust players of gene regulation. Plethora of evidences support that the ability of microRNAs to regulate several genes of a pathway or even multiple cross talking pathways have significant impact on a complex regulatory network and ultimately the physiological processes and diseases. Brain being a complex organ with several cell types, expresses more distinct miRNAs than any other tissues. This review aims to discuss about the microRNAs in brain development, function and their dysfunction in brain tumors. We also provide a comprehensive summary of targets of brain specific and brain enriched miRNAs that contribute to the diversity and plasticity of the brain. In particular, we uncover recent findings on miRNA-128, a brain-enriched microRNA that is induced during neuronal differentiation and whose aberrant expression has been reported in several cancers. This review describes the wide spectrum of targets of miRNA-128 that have been identified till date with potential roles in apoptosis, angiogenesis, proliferation, cholesterol metabolism, self renewal, invasion and cancer progression and how this knowledge might be exploited for the development of future miRNA-128 based therapies for the treatment of cancer as well as metabolic diseases. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 229 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Czechia | 2 | <1% |
| Germany | 1 | <1% |
| Malaysia | 1 | <1% |
| Brazil | 1 | <1% |
| Italy | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 221 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 52 | 23% |
| Student > Master | 34 | 15% |
| Student > Bachelor | 29 | 13% |
| Researcher | 27 | 12% |
| Student > Doctoral Student | 15 | 7% |
| Other | 24 | 10% |
| Unknown | 48 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 59 | 26% |
| Biochemistry, Genetics and Molecular Biology | 43 | 19% |
| Neuroscience | 28 | 12% |
| Medicine and Dentistry | 25 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 2% |
| Other | 15 | 7% |
| Unknown | 55 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2018.
All research outputs
#7,356,343
of 25,374,917 outputs
Outputs from Molecular Cancer
#587
of 1,918 outputs
Outputs of similar age
#67,076
of 239,315 outputs
Outputs of similar age from Molecular Cancer
#9
of 42 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,918 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 67% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,315 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.