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Simple, sensitive and rapid determination of linifanib (ABT-869), a novel tyrosine kinase inhibitor in rat plasma by UHPLC-MS/MS

Overview of attention for article published in BMC Chemistry, February 2014
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Title
Simple, sensitive and rapid determination of linifanib (ABT-869), a novel tyrosine kinase inhibitor in rat plasma by UHPLC-MS/MS
Published in
BMC Chemistry, February 2014
DOI 10.1186/1752-153x-8-13
Pubmed ID
Authors

Muzaffar Iqbal, Essam Ezzeldin, Tanveer A Wani, Nasr Y Khalil

Abstract

Linifanib (ABT-869) is an orally active receptor tyrosine kinase inhibitor, which simultaneously inhibits vascular endothelial and platelet derived growth factor receptor. The aim of the present study was to develop an UHPLC-MS/MS method for the quantification of linifanib in rat plasma to support the pharmacokinetic and toxicokinetic studies.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 5 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 2 40%
Student > Master 1 20%
Unknown 2 40%
Readers by discipline Count As %
Computer Science 1 20%
Agricultural and Biological Sciences 1 20%
Chemistry 1 20%
Unknown 2 40%