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Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells

Overview of attention for article published in BMC Cancer, February 2011
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1 tweeter

Citations

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57 Mendeley
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Title
Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells
Published in
BMC Cancer, February 2011
DOI 10.1186/1471-2407-11-81
Pubmed ID
Authors

Wataru Habano, Toshie Gamo, Jun Terashima, Tamotsu Sugai, Koki Otsuka, Go Wakabayashi, Shogo Ozawa

Abstract

Pregnane X receptor (PXR) is a key transcription factor that regulates drug metabolizing enzymes such as cytochrome P450 (CYP) 3A4, and plays important roles in intestinal first-pass metabolism. Although there is a large inter-individual heterogeneity with intestinal CYP3A4 expression and activity, the mechanism driving these differences is not sufficiently explained by genetic variability of PXR or CYP3A4. We examined whether epigenetic mechanisms are involved in the regulation of PXR/CYP3A4 pathways in colon cancer cells.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
Denmark 1 2%
Unknown 55 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 23%
Researcher 12 21%
Student > Master 11 19%
Student > Postgraduate 5 9%
Student > Doctoral Student 4 7%
Other 7 12%
Unknown 5 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 30%
Medicine and Dentistry 15 26%
Biochemistry, Genetics and Molecular Biology 10 18%
Pharmacology, Toxicology and Pharmaceutical Science 4 7%
Computer Science 2 4%
Other 3 5%
Unknown 6 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2014.
All research outputs
#3,059,914
of 4,507,509 outputs
Outputs from BMC Cancer
#1,508
of 2,430 outputs
Outputs of similar age
#74,415
of 111,660 outputs
Outputs of similar age from BMC Cancer
#77
of 121 outputs
Altmetric has tracked 4,507,509 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,430 research outputs from this source. They receive a mean Attention Score of 2.4. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 111,660 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.