Title |
Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer
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Published in |
Acta Neuropathologica Communications, February 2014
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DOI | 10.1186/2051-5960-2-24 |
Pubmed ID | |
Authors |
Helen Ling, Eleanna Kara, Tamas Revesz, Andrew J Lees, Gordon T Plant, Davide Martino, Henry Houlden, John Hardy, Janice L Holton |
Abstract |
We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60's followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired postural reflexes. Pathological examination demonstrated 4-repeat tau neuronal and glial lesions, including tufted astrocytes, consistent with a diagnosis of progressive supranuclear palsy. In addition, neurofibrillary tangles composed of mixed 3-repeat and 4-repeat tau and astrocytic tangles in a distribution highly suggestive of chronic traumatic encephalopathy were observed together with limbic TDP-43 pathology. Possible mechanisms for the co-occurrence of these two tau pathologies are discussed. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 2% |
United States | 1 | 2% |
Unknown | 59 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 20% |
Researcher | 9 | 15% |
Student > Bachelor | 7 | 11% |
Student > Master | 7 | 11% |
Student > Doctoral Student | 4 | 7% |
Other | 8 | 13% |
Unknown | 14 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 17 | 28% |
Neuroscience | 7 | 11% |
Psychology | 6 | 10% |
Nursing and Health Professions | 4 | 7% |
Sports and Recreations | 4 | 7% |
Other | 7 | 11% |
Unknown | 16 | 26% |