Title |
Controlled release delivery of penciclovir via a silicone (MED-4750) polymer: kinetics of drug delivery and efficacy in preventing primary feline herpesvirus infection in culture
|
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Published in |
Virology Journal, February 2014
|
DOI | 10.1186/1743-422x-11-34 |
Pubmed ID | |
Authors |
Samantha L Semenkow, Nicole M Johnson, David J Maggs, Barry J Margulies |
Abstract |
Herpesviruses are ubiquitous pathogens that infect and cause recurrent disease in multiple animal species. Feline herpesvirus-1 (FHV-1), a member of the alphaherpesvirus family, causes respiratory illness and conjunctivitis, and approximately 80% of domestic cats are latently infected. Oral administration of famciclovir or topical application of cidofovir has been shown in masked, placebo-controlled prospective trials to reduce clinical signs and viral shedding in experimentally inoculated cats. However, to the authors' knowledge, other drugs have not been similarly assessed or were not safe or effective. Likewise, to our knowledge, no drugs have been assessed in a placebo-controlled manner in cats with recrudescent herpetic disease. Controlled-release devices would permit long-term administration of these drugs and enhance compliance. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | 5% |
Unknown | 21 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 5 | 23% |
Student > Ph. D. Student | 3 | 14% |
Student > Bachelor | 3 | 14% |
Student > Doctoral Student | 2 | 9% |
Professor > Associate Professor | 2 | 9% |
Other | 5 | 23% |
Unknown | 2 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 5 | 23% |
Biochemistry, Genetics and Molecular Biology | 3 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 9% |
Medicine and Dentistry | 2 | 9% |
Immunology and Microbiology | 2 | 9% |
Other | 4 | 18% |
Unknown | 4 | 18% |