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Controlled release delivery of penciclovir via a silicone (MED-4750) polymer: kinetics of drug delivery and efficacy in preventing primary feline herpesvirus infection in culture

Overview of attention for article published in Virology Journal, February 2014
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3 X users

Citations

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22 Mendeley
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Title
Controlled release delivery of penciclovir via a silicone (MED-4750) polymer: kinetics of drug delivery and efficacy in preventing primary feline herpesvirus infection in culture
Published in
Virology Journal, February 2014
DOI 10.1186/1743-422x-11-34
Pubmed ID
Authors

Samantha L Semenkow, Nicole M Johnson, David J Maggs, Barry J Margulies

Abstract

Herpesviruses are ubiquitous pathogens that infect and cause recurrent disease in multiple animal species. Feline herpesvirus-1 (FHV-1), a member of the alphaherpesvirus family, causes respiratory illness and conjunctivitis, and approximately 80% of domestic cats are latently infected. Oral administration of famciclovir or topical application of cidofovir has been shown in masked, placebo-controlled prospective trials to reduce clinical signs and viral shedding in experimentally inoculated cats. However, to the authors' knowledge, other drugs have not been similarly assessed or were not safe or effective. Likewise, to our knowledge, no drugs have been assessed in a placebo-controlled manner in cats with recrudescent herpetic disease. Controlled-release devices would permit long-term administration of these drugs and enhance compliance.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 5%
Unknown 21 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 23%
Student > Ph. D. Student 3 14%
Student > Bachelor 3 14%
Student > Doctoral Student 2 9%
Professor > Associate Professor 2 9%
Other 5 23%
Unknown 2 9%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 5 23%
Biochemistry, Genetics and Molecular Biology 3 14%
Pharmacology, Toxicology and Pharmaceutical Science 2 9%
Medicine and Dentistry 2 9%
Immunology and Microbiology 2 9%
Other 4 18%
Unknown 4 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2014.
All research outputs
#14,190,698
of 22,745,803 outputs
Outputs from Virology Journal
#1,598
of 3,036 outputs
Outputs of similar age
#121,188
of 224,804 outputs
Outputs of similar age from Virology Journal
#46
of 65 outputs
Altmetric has tracked 22,745,803 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,036 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.6. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,804 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 65 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.