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CANnabinoid Receptor Type 2 Activation Induces a Microglial Anti-Inflammatory Phenotype and Reduces Migration via MKP Induction and ERK Dephosphorylation

Overview of attention for article published in Molecular Pain, January 2009
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1 X user

Citations

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133 Dimensions

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Title
CANnabinoid Receptor Type 2 Activation Induces a Microglial Anti-Inflammatory Phenotype and Reduces Migration via MKP Induction and ERK Dephosphorylation
Published in
Molecular Pain, January 2009
DOI 10.1186/1744-8069-5-25
Pubmed ID
Authors

Edgar Alfonso Romero-Sandoval, Ryan Horvath, Russell P Landry, Joyce A DeLeo

Abstract

Cannabinoid receptor type 2 (CBR2) inhibits microglial reactivity through a molecular mechanism yet to be elucidated. We hypothesized that CBR2 activation induces an anti-inflammatory phenotype in microglia by inhibiting extracellular signal-regulated kinase (ERK) pathway, via mitogen-activated protein kinase-phosphatase (MKP) induction. MKPs regulate mitogen activated protein kinases, but their role in the modulation of microglial phenotype is not fully understood.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 131 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 2 2%
Germany 2 2%
Spain 1 <1%
United States 1 <1%
Unknown 125 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 25 19%
Student > Ph. D. Student 24 18%
Student > Master 14 11%
Researcher 11 8%
Professor > Associate Professor 8 6%
Other 29 22%
Unknown 20 15%
Readers by discipline Count As %
Medicine and Dentistry 27 21%
Agricultural and Biological Sciences 25 19%
Biochemistry, Genetics and Molecular Biology 16 12%
Neuroscience 14 11%
Pharmacology, Toxicology and Pharmaceutical Science 7 5%
Other 13 10%
Unknown 29 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 February 2014.
All research outputs
#17,285,668
of 25,374,647 outputs
Outputs from Molecular Pain
#372
of 669 outputs
Outputs of similar age
#156,101
of 183,280 outputs
Outputs of similar age from Molecular Pain
#19
of 24 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,280 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.