Title |
Development of a novel antimicrobial-releasing glass ionomer cement functionalized with chlorhexidine hexametaphosphate nanoparticles
|
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Published in |
Journal of Nanobiotechnology, January 2014
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DOI | 10.1186/1477-3155-12-3 |
Pubmed ID | |
Authors |
Edward R Hook, Olivia J Owen, Candice A Bellis, James A Holder, Dominic J O’Sullivan, Michele E Barbour |
Abstract |
Glass ionomer cements (GICs) are a class of dental biomaterials. They have a wide range of uses including permanent restorations (fillings), cavity linings, fissure sealants and adhesives. One of the most common reasons for replacing a dental restoration is recurrent bacterial tooth decay around the margins of the biomaterial. Therefore, a dental biomaterial which creates a sustained antimicrobial environment around the restoration would be of considerable clinical benefit. In this manuscript, the formulation of a GIC containing novel antimicrobial nanoparticles composed of chlorhexidine hexametaphosphate at 1, 2, 5, 10 and 20% powder substitution by mass is reported. The aim is to create GICs which contain chlorhexidine-hexametaphosphate nanoparticles and characterize the nanoparticle size, morphology and charge and the release of chlorhexidine and fluoride, tensile strength and morphology of the GICs. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 2% |
Mexico | 1 | 1% |
Romania | 1 | 1% |
Unknown | 86 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 18 | 20% |
Student > Master | 15 | 17% |
Student > Bachelor | 9 | 10% |
Student > Postgraduate | 6 | 7% |
Student > Doctoral Student | 6 | 7% |
Other | 15 | 17% |
Unknown | 21 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 36 | 40% |
Materials Science | 8 | 9% |
Chemistry | 7 | 8% |
Engineering | 4 | 4% |
Nursing and Health Professions | 3 | 3% |
Other | 9 | 10% |
Unknown | 23 | 26% |