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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Epigenetics in the pathogenesis of rheumatoid arthritis
|
|---|---|
| Published in |
BMC Medicine, February 2014
|
| DOI | 10.1186/1741-7015-12-35 |
| Pubmed ID | |
| Authors |
Tibor T Glant, Katalin Mikecz, Tibor A Rauch |
| Abstract |
An increasing number of studies show that besides the inherited genetic architecture (that is, genomic DNA), various environmental factors significantly contribute to the etiology of rheumatoid arthritis. Epigenetic factors react to external stimuli and form bridges between the environment and the genetic information-harboring DNA. Epigenetic mechanisms are implicated in the final interpretation of the encoded genetic information by regulating gene expression, and alterations in their profile influence the activity of the immune system. Overall, epigenetic mechanisms further increase the well-known complexity of rheumatoid arthritis by providing additional subtle contributions to rheumatoid arthritis susceptibility. Although there are controversies regarding the involvement of epigenetic and genetic factors in rheumatoid arthritis etiology, it is becoming obvious that the two systems (genetic and epigenetic) interact with each other and are ultimately responsible for rheumatoid arthritis development. Here, epigenetic factors and mechanisms involved in rheumatoid arthritis are reviewed and new, potential therapeutic targets are discussed. |
X Demographics
The data shown below were collected from the profiles of 13 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 38% |
| United States | 2 | 15% |
| Nepal | 1 | 8% |
| Unknown | 5 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 77% |
| Scientists | 2 | 15% |
| Practitioners (doctors, other healthcare professionals) | 1 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 213 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | <1% |
| Unknown | 211 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 51 | 24% |
| Student > Master | 33 | 15% |
| Student > Ph. D. Student | 32 | 15% |
| Researcher | 25 | 12% |
| Student > Doctoral Student | 13 | 6% |
| Other | 32 | 15% |
| Unknown | 27 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 51 | 24% |
| Biochemistry, Genetics and Molecular Biology | 35 | 16% |
| Agricultural and Biological Sciences | 32 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 7% |
| Nursing and Health Professions | 12 | 6% |
| Other | 31 | 15% |
| Unknown | 38 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2014.
All research outputs
#4,576,972
of 23,340,595 outputs
Outputs from BMC Medicine
#2,128
of 3,513 outputs
Outputs of similar age
#44,811
of 222,451 outputs
Outputs of similar age from BMC Medicine
#35
of 56 outputs
Altmetric has tracked 23,340,595 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,513 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 44.1. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 222,451 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.