Title |
11q deletion in neuroblastoma: a review of biological and clinical implications
|
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Published in |
Molecular Cancer, June 2017
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DOI | 10.1186/s12943-017-0686-8 |
Pubmed ID | |
Authors |
Vid Mlakar, Simona Jurkovic Mlakar, Gonzalo Lopez, John M. Maris, Marc Ansari, Fabienne Gumy-Pause |
Abstract |
Deletion of the long arm of chromosome 11 (11q deletion) is one of the most frequent events that occur during the development of aggressive neuroblastoma. Clinically, 11q deletion is associated with higher disease stage and decreased survival probability. During the last 25 years, extensive efforts have been invested to identify the precise frequency of 11q aberrations in neuroblastoma, the recurrently involved genes, and to understand the molecular mechanisms of 11q deletion, but definitive answers are still unclear. In this review, it is our intent to compile and review the evidence acquired to date on 11q deletion in neuroblastoma. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 115 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 19 | 17% |
Student > Ph. D. Student | 18 | 16% |
Researcher | 11 | 10% |
Student > Master | 9 | 8% |
Student > Postgraduate | 5 | 4% |
Other | 15 | 13% |
Unknown | 38 | 33% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 33 | 29% |
Medicine and Dentistry | 16 | 14% |
Agricultural and Biological Sciences | 10 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 5% |
Computer Science | 4 | 3% |
Other | 6 | 5% |
Unknown | 40 | 35% |