Title |
Proper connectivity of Drosophila motion detector neurons requires Atonal function in progenitor cells
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Published in |
Neural Development, February 2014
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DOI | 10.1186/1749-8104-9-4 |
Pubmed ID | |
Authors |
Carlos Oliva, Ching-Man Choi, Laura J J Nicolai, Natalia Mora, Natalie De Geest, Bassem A Hassan |
Abstract |
Vertebrates and invertebrates obtain visual motion information by channeling moving visual cues perceived by the retina through specific motion sensitive synaptic relays in the brain. In Drosophila, the series of synaptic relays forming the optic lobe are known as the lamina, medulla, lobula and lobula plate neuropiles. The fly's motion detection output neurons, called the T4 and T5 cells, reside in the lobula plate. Adult optic lobe neurons are derived from larval neural progenitors in two proliferating compartments known as the outer and inner proliferation centers (OPC and IPC). Important insight has been gained into molecular mechanisms involved in the development of the lamina and medulla from the OPC, though less is known about the development of the lobula and lobula plate. |
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