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Forced swim test induces divergent global transcriptomic alterations in the hippocampus of high versus low novelty-seeker rats

Overview of attention for article published in Human Genomics, February 2014
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Title
Forced swim test induces divergent global transcriptomic alterations in the hippocampus of high versus low novelty-seeker rats
Published in
Human Genomics, February 2014
DOI 10.1186/1479-7364-8-4
Pubmed ID
Authors

Pothitos M Pitychoutis, Despina Sanoudou, Margarita Papandreou, Dimitris Nasias, Marianna Kouskou, Craig R Tomlinson, Panagiotis A Tsonis, Zeta Papadopoulou-Daifoti

Abstract

Many neuropsychiatric disorders, including stress-related mood disorders, are complex multi-parametric syndromes. Susceptibility to stress and depression is individually different. The best animal model of individual differences that can be used to study the neurobiology of affect regards spontaneous reactions to novelty. Experimentally, when naive rats are exposed to the stress of a novel environment, they display a highly variable exploratory activity and are classified as high or low responders (HR or LR, respectively). Importantly, HR and LR rats do not seem to exhibit a substantial differentiation in relation to their 'depressive-like' status in the forced swim test (FST), a widely used animal model of 'behavioral despair'. In the present study, we investigated whether FST exposure would be accompanied by phenotype-dependent differences in hippocampal gene expression in HR and LR rats.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 3%
Argentina 1 3%
Unknown 33 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 37%
Student > Master 5 14%
Researcher 4 11%
Student > Bachelor 3 9%
Other 2 6%
Other 3 9%
Unknown 5 14%
Readers by discipline Count As %
Neuroscience 9 26%
Agricultural and Biological Sciences 4 11%
Biochemistry, Genetics and Molecular Biology 3 9%
Sports and Recreations 3 9%
Unspecified 2 6%
Other 7 20%
Unknown 7 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 February 2014.
All research outputs
#20,656,820
of 25,374,647 outputs
Outputs from Human Genomics
#463
of 564 outputs
Outputs of similar age
#173,275
of 234,813 outputs
Outputs of similar age from Human Genomics
#3
of 5 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 564 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
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