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Regulating autonomic nervous system homeostasis improves pulmonary function in rabbits with acute lung injury

Overview of attention for article published in BMC Pulmonary Medicine, July 2017
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Title
Regulating autonomic nervous system homeostasis improves pulmonary function in rabbits with acute lung injury
Published in
BMC Pulmonary Medicine, July 2017
DOI 10.1186/s12890-017-0436-0
Pubmed ID
Authors

Yan Liu, Tao Tao, Wenzhi Li, Yulong Bo

Abstract

This study aimed to investigate the effects of regulating autonomic nervous system (ANS) homeostasis by inhibiting sympathetic hyperactivity and/or enhancing parasympathetic activity on pulmonary inflammation and functional disturbance. An animal model of acute lung injury (ALI) was established in rabbits by an intratracheal injection of hydrochloric acid (HCl) in rabbits. Animals in control groups were received saline or HCl only, and the others received both HCl and followed treatments: vagus nerve stimulation (VNS), intravenous injection of tetrahydroaminoacridine (THA), or stellate ganglion block (SGB). The effects of different treatments on the changes in autonomic nervous system homeostasis, pulmonary and systemic inflammation, and functional disturbance were detected. Sympathetic nervous activity was higher than parasympathetic nervous activity in rabbits after HCl aspiration, as demonstrated by the significant changes in the discharge frequency of cervical sympathetic/vagus trunk, and heart rate variability. VNS, THA and SGB could significantly alleviate the changes of ANS induced by HCl aspiration and improved the pulmonary function, especially for SGB treatment. The disturbance of ANS homeostasis is attributed to a predominance of SNS activity. Administration of VNS, THA and SGB are capable to regulate disequilibrium of the ANS in rabbits with HCl-induced ALI and SGB is supposed to be the most effective approach.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Other 4 14%
Student > Master 3 10%
Student > Bachelor 3 10%
Professor > Associate Professor 2 7%
Lecturer 1 3%
Other 2 7%
Unknown 14 48%
Readers by discipline Count As %
Medicine and Dentistry 10 34%
Neuroscience 2 7%
Nursing and Health Professions 1 3%
Agricultural and Biological Sciences 1 3%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 0 0%
Unknown 14 48%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 May 2022.
All research outputs
#14,353,790
of 22,985,065 outputs
Outputs from BMC Pulmonary Medicine
#874
of 1,945 outputs
Outputs of similar age
#175,156
of 313,820 outputs
Outputs of similar age from BMC Pulmonary Medicine
#19
of 31 outputs
Altmetric has tracked 22,985,065 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,945 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,820 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.