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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells
|
|---|---|
| Published in |
BMC Cancer, January 2014
|
| DOI | 10.1186/1471-2407-14-32 |
| Pubmed ID | |
| Authors |
Jian Kang, C Marcelo Sergio, Robert L Sutherland, Elizabeth A Musgrove |
| Abstract |
Although MYC is an attractive therapeutic target for breast cancer treatment, it has proven challenging to inhibit MYC directly, and clinically effective pharmaceutical agents targeting MYC are not yet available. An alternative approach is to identify genes that are synthetically lethal in MYC-dependent cancer. Recent studies have identified several cell cycle kinases as MYC synthetic-lethal genes. We therefore investigated the therapeutic potential of specific cyclin-dependent kinase (CDK) inhibition in MYC-driven breast cancer. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Romania | 1 | 33% |
| Grenada | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
| Scientists | 1 | 33% |
| Members of the public | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| Netherlands | 1 | <1% |
| Canada | 1 | <1% |
| Spain | 1 | <1% |
| Japan | 1 | <1% |
| Unknown | 132 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 28% |
| Researcher | 24 | 17% |
| Student > Master | 17 | 12% |
| Student > Bachelor | 16 | 12% |
| Student > Doctoral Student | 5 | 4% |
| Other | 15 | 11% |
| Unknown | 23 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 38 | 28% |
| Agricultural and Biological Sciences | 35 | 25% |
| Medicine and Dentistry | 19 | 14% |
| Chemistry | 7 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 1% |
| Other | 7 | 5% |
| Unknown | 30 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 November 2022.
All research outputs
#4,077,260
of 23,063,209 outputs
Outputs from BMC Cancer
#976
of 8,374 outputs
Outputs of similar age
#49,062
of 307,022 outputs
Outputs of similar age from BMC Cancer
#13
of 115 outputs
Altmetric has tracked 23,063,209 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,374 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,022 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 115 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.