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Inflammatory and cytotoxic effects of acrolein, nicotine, acetylaldehyde and cigarette smoke extract on human nasal epithelial cells

Overview of attention for article published in BMC Pulmonary Medicine, March 2014
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Title
Inflammatory and cytotoxic effects of acrolein, nicotine, acetylaldehyde and cigarette smoke extract on human nasal epithelial cells
Published in
BMC Pulmonary Medicine, March 2014
DOI 10.1186/1471-2466-14-32
Pubmed ID
Authors

David M Comer, Joseph Stuart Elborn, Madeleine Ennis

Abstract

Cigarette smoke induces a pro-inflammatory response in airway epithelial cells but it is not clear which of the various chemicals contained within cigarette smoke (CS) should be regarded as predominantly responsible for these effects. We hypothesised that acrolein, nicotine and acetylaldehyde, important chemicals contained within volatile cigarette smoke in terms of inducing inflammation and causing addiction, have immunomodulatory effects in primary nasal epithelial cell cultures (PNECs).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 66 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 24%
Student > Bachelor 12 18%
Student > Master 11 17%
Researcher 11 17%
Lecturer 2 3%
Other 3 5%
Unknown 11 17%
Readers by discipline Count As %
Medicine and Dentistry 16 24%
Agricultural and Biological Sciences 14 21%
Biochemistry, Genetics and Molecular Biology 8 12%
Immunology and Microbiology 2 3%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 9 14%
Unknown 15 23%