Title |
Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties
|
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Published in |
Cancer Cell International, March 2014
|
DOI | 10.1186/1475-2867-14-20 |
Pubmed ID | |
Authors |
Tsung-Hsien Wu, Yu-Wei Chou, Pei-Hung Chiu, Ming-Jer Tang, Chun-Wen Hu, Ming-Long Yeh |
Abstract |
In vivo, the transforming growth factor-beta1 (TGF-β1)-induced epithelial to mesenchymal transition (EMT) occurs in seconds during cancer cells intravasation and extravasation. Although it has been established that cellular stiffness can change as a cancer cell transformed, the precise relationship between TGF-β1-induced mesenchymal stem cell mechanics and cancer prognosis remains unclear. Accordingly, it is hard to define the effects of EMT on cell mechanical properties (CMs), tumor recurrence and metastasis risks. This study bridges physical and pathological disciplines to reconcile single-cell mechanical measurements of tumor cells. |
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Members of the public | 1 | 100% |
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Researcher | 5 | 21% |
Student > Ph. D. Student | 3 | 13% |
Student > Master | 3 | 13% |
Student > Bachelor | 2 | 8% |
Professor > Associate Professor | 2 | 8% |
Other | 5 | 21% |
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Medicine and Dentistry | 2 | 8% |
Other | 2 | 8% |
Unknown | 5 | 21% |