Title |
Computational prediction of the human-microbial oral interactome
|
---|---|
Published in |
BMC Systems Biology, February 2014
|
DOI | 10.1186/1752-0509-8-24 |
Pubmed ID | |
Authors |
Edgar D Coelho, Joel P Arrais, Sérgio Matos, Carlos Pereira, Nuno Rosa, Maria José Correia, Marlene Barros, José Luís Oliveira |
Abstract |
The oral cavity is a complex ecosystem where human chemical compounds coexist with a particular microbiota. However, shifts in the normal composition of this microbiota may result in the onset of oral ailments, such as periodontitis and dental caries. In addition, it is known that the microbial colonization of the oral cavity is mediated by protein-protein interactions (PPIs) between the host and microorganisms. Nevertheless, this kind of PPIs is still largely undisclosed. To elucidate these interactions, we have created a computational prediction method that allows us to obtain a first model of the Human-Microbial oral interactome. |
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Mendeley readers
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Other | 14 | 15% |
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Immunology and Microbiology | 5 | 5% |
Other | 11 | 11% |
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