↓ Skip to main content

Epigenetic silencing of miR-375 induces trastuzumab resistance in HER2-positive breast cancer by targeting IGF1R

Overview of attention for article published in BMC Cancer, February 2014
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

twitter
3 tweeters

Citations

dimensions_citation
98 Dimensions

Readers on

mendeley
61 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Epigenetic silencing of miR-375 induces trastuzumab resistance in HER2-positive breast cancer by targeting IGF1R
Published in
BMC Cancer, February 2014
DOI 10.1186/1471-2407-14-134
Pubmed ID
Authors

Xing-Ming Ye, Hua-Yu Zhu, Wen-Dong Bai, Ting Wang, Lei Wang, Ying Chen, An-Gang Yang, Lin-Tao Jia

Abstract

Resistance to humanized monoclonal erbB2/HER2 antibody, trastuzumab (Herceptin), has become a pivotal obstacle for targeted therapy of HER2-positive breast cancers. The activation of alternative growth factor receptors, in particular, the insulin-like growth factor 1 receptor (IGF1R), represents a common feature of trastuzumab-refractory cells; however, the underlying mechanism remains elusive.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 2%
Portugal 1 2%
Poland 1 2%
Austria 1 2%
Unknown 57 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 33%
Student > Master 11 18%
Researcher 7 11%
Student > Bachelor 5 8%
Professor 2 3%
Other 7 11%
Unknown 9 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 28%
Biochemistry, Genetics and Molecular Biology 14 23%
Medicine and Dentistry 10 16%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Computer Science 2 3%
Other 5 8%
Unknown 11 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 April 2014.
All research outputs
#2,167,563
of 5,036,908 outputs
Outputs from BMC Cancer
#766
of 2,818 outputs
Outputs of similar age
#47,323
of 122,717 outputs
Outputs of similar age from BMC Cancer
#33
of 127 outputs
Altmetric has tracked 5,036,908 research outputs across all sources so far. This one has received more attention than most of these and is in the 55th percentile.
So far Altmetric has tracked 2,818 research outputs from this source. They receive a mean Attention Score of 2.6. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,717 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 127 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.