Title |
Resolution of central nervous system astrocytic and endothelial sources of CCL2 gene expression during evolving neuroinflammation
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Published in |
Fluids and Barriers of the CNS, March 2014
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DOI | 10.1186/2045-8118-11-6 |
Pubmed ID | |
Authors |
Bandana Shrestha, Shujun Ge, Joel S Pachter |
Abstract |
The chemokine CCL2 is a critical mediator of neuroinflammation in diseases such as multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). CCL2 drives mononuclear cell infiltration into the central nervous system (CNS), alters expression and distribution of microvascular endothelial tight junction proteins, and disrupts the blood-brain and blood-spinal cord barriers. Immunohistochemistry has consistently revealed astrocytes to be a source of this chemokine during neuroinflammation, while providing less uniform evidence that CNS endothelial cells may also express CCL2. Moreover, the relative contributions of these cell types to the CNS pool of CCL2 during MS/EAE are unclear and the aim of this study was to investigate this further. |
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United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Demographic breakdown
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Student > Master | 5 | 16% |
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Professor > Associate Professor | 2 | 6% |
Student > Doctoral Student | 2 | 6% |
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Unknown | 2 | 6% |
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